Expansion of T-Cell Receptor dim Effector T Cells in Acute Coronary Syndromes
نویسندگان
چکیده
elevated levels of C-reactive protein, and it persisted after the acute event. Moreover, TCR dim cells were also more represented within CD8 T cell, NK, and CD4 CD28 T cell subsets in ACS compared to CSA and controls. Finally, CD4 and CD8 TCR dim T cells isolated from ACS displayed an enhanced transendothelial migratory capacity. Conclusions—TCR dim T cells, an effector T-cell subset with transendothelial migratory ability, are increased in ACS, and
منابع مشابه
Effect of Anti-CD3/CD28 Dynabeads and Allogeneic PBMCs on Expansion of Anti-MUC1 Chimeric Receptor T Cells
Background and purpose: In recent years, immunotherapy using chimeric antigen receptor T cells (CAR T cells) has been considered as a novel and promising treatment for some diseases, especially cancer. The CAR T cell production is a multi-step, complex, time-consuming, and costly process. One of the most important steps in production of CAR T cells is expansion of these cells at appropriate num...
متن کاملAltered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes.
OBJECTIVE Inflammation in response to oxidized lipoproteins is thought to play a key role in acute coronary syndromes (ACS), but the pattern of immune activation has not been fully characterized. We sought to perform detailed phenotypic and functional analysis of CD8 T lymphocytes from patients presenting with ACS to determine activation patterns and potential immunologic correlates of ACS. A...
متن کاملTCRζdimlymphocytes define populations of circulating effector cells that migrate to inflamed tissues
The T-cell receptor zeta (TCRzeta) chain is a master sensor and regulator of lymphocyte responses. Loss of TCRzeta expression has been documented in infectious, inflammatory, and malignant diseases, suggesting that it may serve to limit T-cell reactivity and effector responses at sites of tissue damage. These observations prompted us to explore the relationship between TCRzeta expression and ef...
متن کاملAntigen-independent targeting of long-lived CD4+ cytolytic T effector cells to lesions of atherosclerosis.
Acute coronary syndromes, most often characterized by fissuring or rupture of coronary lesions, are responsible for the majority of clinical manifestations of atherosclerosis.1–3 Studies of human atherosclerotic plaques after acute events have revealed that lesions that tend to rupture are rich in inflammatory cells and have a thin fibrous cap, implicating the inflammatory response as a key reg...
متن کاملفنوتایپینگ لنفوسیتهای T خاطرهای در گردش در سالک
Background and Aim: The heterogenous population of memory T lymphocytes is distinguished based on surface markers and effector functions such as cytokine secretion. Recently, two subsets of memory T cells are defined by expression of chemokine receptor CCR7 and CD45RA designating as "central memory" T cells (TCM) and "effector memory" T cells (TEM). The objective of this staudy was to evaluate ...
متن کامل